During the brief War with Nazi Germany various shadowy governmental organisations worked on artificially creating Superladies to aid their armies. The British SOE was by far the most successful at this thanks to their backing from all of the original Superladies (Heroines and Villainesses alike.)
Well successful in creating many powerful individuals however the vast majority of Experiments, even if they remain on the right side of the law, go more than a little crazy. With the defection of former propaganda project Major Britannia to the LEO post-war further experimentation was outlawed worldwide.
Of course that doesn’t mean it’s not happening.
Experiments tend to be extremely good defensive fighters however they are prone to mental instability and have proven highly suggestible.